Serrapeptase: What it is and why people try it

Here’s a straightforward fact: serrapeptase is an enzyme some people use for pain and inflammation, but the evidence is mixed. Originally discovered in silkworms, it’s marketed as serratiopeptidase and sold as an oral supplement for conditions like sinusitis, post-surgery swelling, and chronic pain. Before you buy or try it, you should know what works, what’s risky, and how to pick a reliable product.

What the research says — honest and short

Small trials show serrapeptase can reduce mucus and swelling in sinusitis and may help with pain after surgery. But most studies are limited in size or quality, so results aren’t rock-solid. It’s not a replacement for proven treatments like antibiotics when you need them, or for doctor-directed care for serious conditions. Think of serrapeptase as a possible add-on, not a cure-all.

Practical dosing, timing, and how to take it

Typical doses in studies range from 10 mg to 60 mg a day or 10,000 to 120,000 units, usually split across meals. Many people take it on an empty stomach so the enzyme reaches the bloodstream rather than acting only in the gut. Follow the product label or a clinician’s advice—don’t guess. If your product lists “units,” don’t assume a direct conversion to mg; follow that brand’s directions.

Common side effects are mild: stomach discomfort, nausea, or skin reactions. There’s a real safety concern with bleeding: serrapeptase may increase bleeding risk or interact with blood thinners (warfarin, aspirin, clopidogrel). Stop taking it at least 2 weeks before surgery and tell your surgeon about any supplements you use. Pregnant or breastfeeding people should avoid it because safety isn’t established.

Drug interactions matter. If you take anticoagulants, antiplatelet drugs, or have a bleeding disorder, don’t use serrapeptase without talking to a doctor. It may also interact with other supplements that affect clotting, like fish oil or high-dose vitamin E.

Buying tips: choose brands that list the enzyme units, have third-party testing, and show clear dosing. Avoid vague products that don’t say where they’re made or what strength they contain. If you buy online, pick a reputable pharmacy or seller with verified reviews and clear return policies. Check expiration dates and store supplements in a cool, dry place.

If you want to try serrapeptase, start low, track results, and set a time to reassess (4–8 weeks). If symptoms don’t improve or you get worse, stop and see a healthcare provider. For many conditions, proven treatments work better and faster—use serrapeptase thoughtfully, not as a substitute for proper care.

Questions about specific brands, dosing conversions, or interactions with your meds? I can help look those up or explain what to ask your doctor.